Relationships Of Vitamin D And Vitamin B12 With Malonaldehyde In Patients With Beta Thalassemia Major

Background: Beta thalassemia major (Cooley's anemia) is a congenital genetic blood disorder resulting from deficiency of β-globin chains due to severe anemia that depends on continuous transfusions for survival. Patients suffer hemoglobinopathy, infection, diabetes mellitus, growth retardation, enlargement and damage the liver spleen, bone marrow aplasia delayed sexual maturity. This complication arises accumulation iron, impairment antioxidants vitamins, an increase in lipid peroxides (MDA).Objectives: The study aimed evaluate vitamin D B12 levels their relationship with MDA, enzymes (AST, ALT, ALP), iron (Total Billirubin, Direct Indirect Billirubin).Materials methods: samples BTM patients under were (100 samples), (50 samples) both males females. Patients' ages ranged (2-30 years). While control sample was (40), (20 each two sexes. Their disease confirmed by tests, hemoglobin electrophoresis, DNA analysis, elevated ferritin levels. Vitamin assessed immunoassay. (MDA, Fe, AST, ALP) Billirubin) evaluated colorimetric methods.Results: decreased significantly (p≤0.05). increased at (p≤0.05) compared group. Where effect according results clear age.
 conclusion: Our indicate weakness antioxidant systems (vitamin B12) oxidative factors complications led exacerbation overload, causing blood, damaging spleen.